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The hangover from a combined opiate and anticholinergic session is almost completely the result of the anticholinergics and is best chased away with nicotine, either a low dose for non-smokers or some chain-smoking for smokers, and its effectiveness ranges from moderate for dimenhydrinate to virtually complete for the muscle relaxant cyclobenzaprine, the normal dose of which is equivalent to the anticholinergic effect of 70 mg of diphenhydramine.

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It is given because a lack of pyridoxine in the body may also be a factor in causing nausea and vomiting during pregnancy.

However, some patients may be susceptible at commonly used dosages, including the elderly, debilitated or severely ill patients, those receiving other CNS depressants, and those with limited ventilatory reserve, chronic pulmonary insufficiency or other respiratory disorders.

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For adults and children 12 years of age and older, 1 caplet should be taken at bedtime, or as directed by a doctor.

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Celexa), escitalopram (Lexapro), fluoxetine (Prozac) and sertraline (Zoloft).

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The "itchies" affect users of oral narcotics above moderate doses and can be reduced in intensity by taking a tablet of clemastine furmarate (Tavist), the new non-drowsy anti-histamines Allegra or Claritin, or meclizine hydrochloride (Dramamine II) an hour before taking the dose of opiates, then using an old fashioned drowsiness producing antihistamine with moderate to strong anticholinergic action like diphenhydramine (Benadryl), dimenhydrinate (Original Dramamine), or brompheniramine (Dimetapp) to boost the effect of the opiate, and using topical creams containing antihistamines to knock down the worst itching.

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